About the PI

Simone Sidoli is an Assistant Professor at the Department of Biochemistry at the Albert Einstein College of Medicine.

He approached mass spectrometry (MS) as a trainee in the laboratory of Prof. Careri at the University of Parma (Italy), his hometown. There, he established methods to detect allergens in aliments, as food and food safety are critical aspects of the economy of Parma. Next, he moved to the University of Southern Denmark (Odense, DK) for his PhD, joining the prestigious Protein Research Group. In the group of Ole N. Jensen, he developed methods for protein analysis, processing large datasets and learned to maintain state-of-the-art instrumentation. Together with the Biotech Research & Innovative Center (BRIC) in Copenhagen, he studied the histone modification landscape of embryonic stem cells using his own developed middle-down MS workflow. Middle-down MS performs unbiased identification and quantification of co-existing histone marks.

In 2014, he joined Ben Garcia’s lab, located within the Epigenetics Institute at the University of Pennsylvania (Philadelphia, PA, USA). In this environment hosting many worldwide famous experts in epigenetics, he investigated human disease systems by developing a proteomics and computational pipeline to link cell signaling cascades (protein phosphorylation) with chromatin changes (histone modifications). He also applied this methodology to identify the regulated proteome during host viral infection. These methods include improvements in quantification accuracy of histone codes, enhancement of throughput, quantification of chromatin accessibility and follow-up optimization of the middle-down MS strategy. Simone has been a member of the American Society of Mass Spectrometry (ASMS), HUman Proteome Organization (HUPO) and the New York Academy of Sciences (NYAS).

Simone joined the Albert Einstein College of Medicine in February 2019, and he kick-started the lab officially in July 2019. He joined the Einstein Cancer Center (link), the Nathan Shock Institute for Aging Research (link), the Einstein-Rockefeller-CUNY Center for AIDS Research (link) and the Einstein Institute for Neuroimmunology and Inflammation (link). Since April 2020, he is also the Scientific Director of the Proteomics Core.